1607
| Sir Christopher Newport explored the James and Appomattox Rivers along the Chesterfield borders five days before the Jamestown was settled
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1612
| Tobacco was first cultivated scientifically in America at Bermuda Hundred by John Rolfe.
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1614
| Bermuda Hundred was incorporated as the first town in America.
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1619
| Falling Creek was the site of the first iron furnace in the New World.
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1621
| Falling Creek was the site of the first lead mines in America.
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1622
| Mount Malady near Dutch Gap was the site of the first American hospital.
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1709
| Midlothian produced the first commercially mined coal in America.
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1795
| Bosher's Dam near Bon Air was the first large multipurpose dam in Virginia.
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1807
| Midlothian Turnpike was the first paved road in Virginia.
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1811
| The first commercial tramway in America, the predecessor of the railroads, was operated from the Brown, Page and Burr gunpowder plant on Falling Creek to its storage magazine a mile away.
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1812
| The first school for deaf mutes in the United States was located at Cobbs on the lower Appomattox.
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1831
| The Midlothian to Manchester Railroad was the first in Virginia.
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1862
| Cpl. John B. Mackie was the U.S. Marine Corps' first recipient of the Medal of Honor, which he was awarded for his brave and courageous conduct while on board the USS Galena during the May 15, 1862 battle of Drewry's Bluff.
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| 1864 | Bermuda Hundred Civil War Campaign - the only campaign fought entirely in one county. |
1921
| Father's day was originated by three ladies from Drewry's Bluff.
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1934
| The first wayside park in Virginia featured the Old Stone Bridge over Falling Creek, completed in 1826.
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